CAS No.: 357400-13-6
(1S,2S)-2-(2-((3-(1H-Benzo[d]imidazol-2-yl)propyl)(methyl)amino)ethyl)-6-fluoro-1-isopropyl-1,2,3,4-tetrahydronaphthalen-2-yl cyclopropanecarboxylate dihydrochloride Catalog No. CSN16645
Synonyms: NNC 55-0396 dihydrochloride
NNC 55-0396, Mibefradil derivative, is a highly selective T-type calcium channel blocker, displaying IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Li M, Hansen JB, et al. Towards selective antagonists of T-type calcium channels: design, characterization and potential applications of NNC 55-0396. Cardiovasc Drug Rev. 2005 Summer;23(2):173-96.
- [2] Huang L, Keyser BM, et al. NNC 55-0396[(1S,2S)-2-(2-(N-[(3-benzimidazol-2-yl)propyl] -N-methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphtyl cyclopropanecarboxylate dihydrochloride] : new selective inhibitor of T-type calcium channels. J Pharmacol Exp Ther. 2004 Apr;309(1):193-9. Epub 2004 Jan 12.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 357400-13-6 | 储存条件 |
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| 分子式 | C30H40Cl2FN3O2 | 运输 | 蓝冰 | |
| 分子量 | 564.56 | 别名 | NNC 55-0396 dihydrochloride |
